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Minutenangaben

2:23 Venenkrankheiten

3:38 Oxidativer Stress und Entzündungen

5:04 Bluthochdruck

7:41 Freie Radikale unschädlich machen

8:27 Erkrankungen im Zusammenhang mit oxidativem Stress, z.B. Gelenkerkrankungen wie Arthrose, Chronisch entzündliche Darmerkrankungen wie Morbus und Crohn und Colitis Ulcerosa, Autoimmunerkrankungen wie Lupus, Hashimoto, rheumatoide Arthritis

11:07 CED: Morbus Crohn, Colitis Ulceroda, Zöliakie

11:39 Rheumatoide Arthritis

11:53 Arthrose

13:16 Wundheilung und Kollagenbildung

13:27 Regeneration nach dem Sport

13:56 Nierenerkrankungen, Nierenversagen

14:45 Cholesterinspiegel

15:08 Insulinresistenz, Diabetes, Insulinsensitivität

15:42 geschwollene Beine

17:22 Psychische Gesundheit: Depressionen, Panikattacken, Bipolare Störung

17:56 Vorbeugung und Behandlung von Alzheimer

18:26 Wirkung im Gehirn - Serotonin

19:09 Parodontose Prävention

Quellenverzeichnis:

(1) Weseler AR, Bast A. Masquelier's grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits. Nutr J. 2017 Jan 19;16(1):5. doi: 10.1186/s12937-016-0218-1. PMID: 28103873; PMCID: PMC5248468. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248468/)

(2) Zhang H, Liu S, Li L, Liu S, Liu S, Mi J, Tian G. The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016 Aug;95(33):e4247. doi: 10.1097/MD.0000000000004247. PMID: 27537554; PMCID: PMC5370781. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/)

(3) Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016 Jan 28;115(2):226-38. doi: 10.1017/S0007114515004328. Epub 2015 Nov 16. PMID: 26568249. (https://pubmed.ncbi.nlm.nih.gov/26568249/)

(4) Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000 Aug 7;148(2-3):187-97. doi: 10.1016/s0300-483x(00)00210-9. PMID: 10962138. (https://pubmed.ncbi.nlm.nih.gov/10962138/)

(5) Wang H, Xue Y, Zhang H, Huang Y, Yang G, Du M, Zhu MJ. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Mol Nutr Food Res. 2013 Dec;57(12):2253-7. doi: 10.1002/mnfr.201300146. Epub 2013 Aug 21. PMID: 23963706; PMCID: PMC3976669. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976669/)

(6) Kim J, So WY. Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial. J Exerc Sci Fit. 2019 Jan 20;17(2):77-79. doi: 10.1016/j.jesf.2019.01.001. Epub 2019 Jan 3. PMID: 30992707; PMCID: PMC6449740. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449740/)

(7) Turki K, Charradi K, Boukhalfa H, Belhaj M, Limam F, Aouani E. Grape seed powder improves renal failure of chronic kidney disease patients. EXCLI J. 2016 Jun 27;15:424-433. doi: 10.17179/excli2016-363. PMID: 27822171; PMCID: PMC5083963. (https://pubmed.ncbi.nlm.nih.gov/27822171/)

(8) Razavi SM, Gholamin S, Eskandari A, Mohsenian N, Ghorbanihaghjo A, Delazar A, Rashtchizadeh N, Keshtkar-Jahromi M, Argani H. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. J Med Food. 2013 Mar;16(3):255-8. doi: 10.1089/jmf.2012.2408. Epub 2013 Feb 25. PMID: 23437789. (https://pubmed.ncbi.nlm.nih.gov/23437789/)

(9) Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009 May;26(5):526-31. doi: 10.1111/j.1464-5491.2009.02727.x. PMID: 19646193. (https://pubmed.ncbi.nlm.nih.gov/19646193/)

(10) Sano A, Tokutake S, Seo A. Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. J Sci Food Agric. 2013 Feb;93(3):457-62. doi: 10.1002/jsfa.5773. Epub 2012 Jul 2. PMID: 22752876. (https://pubmed.ncbi.nlm.nih.gov/22752876/)

(11) Salim S. Oxidative stress and psychological disorders. Curr Neuropharmacol. 2014 Mar;12(2):140-7. doi: 10.2174/1570159X11666131120230309. PMID: 24669208; PMCID: PMC3964745. (https://pubmed.ncbi.nlm.nih.gov/24669208/)

(12) Gengaihi, Souad & Abou Baker, Doha. (2017). Grape Seeds Extract as Brain Food: A Review. International Journal of Pharmaceutical and Clinical Research. 9. 10.25258/ijpcr.v9i1.8270. (https://www.researchgate.net/publication/318353886_Grape_Seeds_Extract_as_Brain_Food_A_Review)

(13) Hritcu L, Ionita R, Postu PA, Gupta GK, Turkez H, Lima TC, Carvalho CUS, de Sousa DP. Antidepressant Flavonoids and Their Relationship with Oxidative Stress. Oxid Med Cell Longev. 2017;2017:5762172. doi: 10.1155/2017/5762172. Epub 2017 Dec 19. PMID: 29410733; PMCID: PMC5749298. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749298/)

(14) Bogdan C, Pop A, Iurian SM, Benedec D, Moldovan ML. Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care. Antioxidants (Basel). 2020 Jun 8;9(6):502. doi: 10.3390/antiox9060502. PMID: 32521718; PMCID: PMC7346141. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346141/)

(15) Effect of grape seed on quality of life in multiple sclerosis patients (http://www.jocms.org/index.php/jcms/article/view/453#)

(16) Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells (https://pubmed.ncbi.nlm.nih.gov/29630472/)